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Authordc.contributor.authorValenzuela, José I. 
Authordc.contributor.authorJaureguiberry Bravo, Matías 
Authordc.contributor.authorSalas, Daniela A. 
Authordc.contributor.authorRamírez, Omar A. 
Authordc.contributor.authorCornejo, Víctor H. 
Authordc.contributor.authorLu, Hsiangmin E. 
Authordc.contributor.authorBlanpied, Thomas A. 
Authordc.contributor.authorCouve Correa, Andrés 
Admission datedc.date.accessioned2018-12-20T14:14:23Z
Available datedc.date.available2018-12-20T14:14:23Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationJournal of Cell Science, Volumen 127, Issue 15, 2018, Pages 3382-3395
Identifierdc.identifier.issn14779137
Identifierdc.identifier.issn00219533
Identifierdc.identifier.other10.1242/jcs.151092
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/155124
Abstractdc.description.abstractIn neurons, secretory organelles within the cell body are complemented by the dendritic endoplasmic reticulum (ER) and Golgi outposts (GOPs), whose role in neurotransmitter receptor trafficking is poorly understood. γ-aminobutyric acid (GABA) type B metabotropic receptors (GABABRs) regulate the efficacy of synaptic transmission throughout the brain. Their plasma membrane availability is controlled by mechanisms involving an ER retention motif and assembly-dependent ER export. Thus, they constitute an ideal molecular model to study ER trafficking, but the extent to which the dendritic ER participates in GABABR biosynthesis has not been thoroughly explored. Here, we show that GABAB1localizes preferentially to the ER in dendrites and moves long distances within this compartment. Not only diffusion but also microtubule and dyneindependent mechanisms control dendritic ER transport. GABABRs insert throughout the somatodendritic plasma membrane but dendritic post-ER carriers containing GABABR
Lenguagedc.language.isoen
Publisherdc.publisherCompany of Biologists Ltd
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Cell Science
Keywordsdc.subjectDendrite
Keywordsdc.subjectEndoplasmic reticulum
Keywordsdc.subjectGABA
Keywordsdc.subjectGolgi outposts
Keywordsdc.subjectNeuron
Keywordsdc.subjectTrafficking
Títulodc.titleTransport along the dendritic endoplasmic reticulum mediates the trafficking of GABAB receptors
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile