Synthesis of N-(halogenated) benzyl analogs of superpotent serotonin ligands
Author
dc.contributor.author
Tirapegui, Cristian
Author
dc.contributor.author
Toro-Sazo, Miguel A.
Author
dc.contributor.author
Cassels Niven, Bruce
Admission date
dc.date.accessioned
2018-12-20T14:14:26Z
Available date
dc.date.available
2018-12-20T14:14:26Z
Publication date
dc.date.issued
2014
Cita de ítem
dc.identifier.citation
Journal of the Chilean Chemical Society, Volumen 59, Issue 3, 2018, Pages 2625-2627
Identifier
dc.identifier.issn
07179707
Identifier
dc.identifier.issn
07179324
Identifier
dc.identifier.other
10.4067/S0717-97072014000300022
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/155147
Abstract
dc.description.abstract
In the last four years a group of extremely potent designer drugs, the N-benzylated phenylethylamines known as the NBOMe series, has surfaced on the street and in the news media. Although data documenting their high affinity and preference for 5-HT2 serotonin receptors abound (5-HT2A receptor activation is generally associated with the action of the "classical" hallucinogens), relatively little is known about the molecular basis of their potency and selectivity. In the setting of a project aiming to evaluate the possible involvement of halogen bonds in the binding of monoaminergic ligands to their receptors, we have begun to synthesize halogenated derivatives of known N-benzylated compounds for their pharmacological study. Here we report the synthesis of new phenylethylamine and tryptamine derivatives incorporating bromine atoms in their N-benzyl moiety.