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Author dc.contributor.author Delgado, Ricardo A.
Author dc.contributor.author Galdámez, Antonio
Author dc.contributor.author Villena, Joan
Author dc.contributor.author Reveco, Patricio G.
Author dc.contributor.author Thomet, Franz A.
Admission date dc.date.accessioned 2018-12-20T14:14:28Z
Available date dc.date.available 2018-12-20T14:14:28Z
Publication date dc.date.issued 2015
Cita de ítem dc.identifier.citation Journal of Organometallic Chemistry, Volumen 782,
Identifier dc.identifier.issn 0022328X
Identifier dc.identifier.other 10.1016/j.jorganchem.2014.09.005
Identifier dc.identifier.uri https://repositorio.uchile.cl/handle/2250/155165
Abstract dc.description.abstract © 2014 Elsevier B.V. All rights reserved. Abstract Five new organometallic Ru(II) compounds (VI-X) with the general formula [Ru(η6-arene)(N,N)Cl]PF6, where arene-N,N correspond to methylisoeugenol-bipyridine (VI); anethole-bipyridine (VII); methylisoeugenol-ethylenediamine (VIII); anethole-ethylenediamine (IX) and methylisoeugenol-1,2-diaminobenzene (X), have been synthesized, fully characterized and biologically evaluated in vitro. The reaction conditions based on the reduction of [Ru(1,5-COD)Cl2]n in situ with methyleugenol and estragole, which are natural ligands, induced an alkene isomerization on the allylic substituent of coordinated arenes. The Ru(II)-arene bond formation and isomerization of the CC bond on the allyl substituent was confirmed using 1H NMR spectroscopy; this result was validated for compound VIII by X-ray diffraction. An XRD analysis revealed the presence of both enantiomers of the complex in the single-crystal. Compounds IX and X exhibited a better cytotoxic act
Lenguage dc.language.iso en
Publisher dc.publisher Elsevier
Type of license dc.rights Attribution-NonCommercial-NoDerivs 3.0 Chile
Link to License dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Source dc.source Journal of Organometallic Chemistry
Keywords dc.subject Bioorganometallic
Keywords dc.subject Cytotoxicity
Keywords dc.subject Natural products
Keywords dc.subject Ru(II) complexes
Título dc.title Synthesis, characterization and in vitro biological evaluation of [Ru(η6-arene)(N,N)Cl]PF6 compounds using the natural products arenes methylisoeugenol and anethole
Document type dc.type Artículo de revista
Cataloguer uchile.catalogador SCOPUS
Indexation uchile.index Artículo de publicación SCOPUS
uchile.cosecha uchile.cosecha SI
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