Caveolin-1 expression increases upon maturation in dendritic cells and promotes their migration to lymph nodes thereby favoring the induction of CD8+ T cell responses
Author
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Oyarce, César
Author
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Cruz Gómez, Sebastián
Author
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Gálvez Cancino, Felipe Ignacio
Author
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Vargas, Pablo
Author
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Moreau, Hélène D.
Author
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Díaz Valdivia, Natalia
Author
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Díaz, Jorge
Author
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Salazar Onfray, Flavio
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Pacheco, Rodrigo
Author
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Lennon Duménil, Ana María
Author
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Quest, Andrew F. G.
Author
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Lladser, Álvaro
Admission date
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2018-12-20T14:15:33Z
Available date
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2018-12-20T14:15:33Z
Publication date
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2017
Cita de ítem
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Frontiers in Immunology, Volumen 8, Issue DEC, 2018,
Identifier
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16643224
Identifier
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10.3389/fimmu.2017.01794
Identifier
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https://repositorio.uchile.cl/handle/2250/155347
Abstract
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Dendritic cell (DC) trafficking from peripheral tissues to lymph nodes (LNs) is a key step required to initiate T cell responses against pathogens as well as tumors. In this context, cellular membrane protrusions and the actin cytoskeleton are essential to guide DC migration towards chemotactic signals. Caveolin-1 (CAV1) is a scaffolding protein that modulates signaling pathways leading to remodeling of the actin cytoskeleton and enhanced migration of cancer cells. However, whether CAV1 is relevant for DC function and specifically for DC migration to LNs is unknown. Here, we show that CAV1 expression is upregulated in DCs upon LPS- and TNF-a-induced maturation. CAV1 deficiency did not affect differentiation, maturation, or the ability of DCs to activate CD8+ T cells in vitro. However, CAV1-deficient (CAV1-/-) DCs displayed reduced in vivo trafficki
Caveolin-1 expression increases upon maturation in dendritic cells and promotes their migration to lymph nodes thereby favoring the induction of CD8+ T cell responses