Effects of some β-carboline alkaloids on intact Trypanosoma cruzi epimastigotes
| Author | dc.contributor.author | Rivas, Pilar | |
| Author | dc.contributor.author | Cassels Niven, Bruce | |
| Author | dc.contributor.author | Morello Casté, Antonio | |
| Author | dc.contributor.author | Repetto Scaramelli, Yolanda | |
| Admission date | dc.date.accessioned | 2018-12-20T14:28:39Z | |
| Available date | dc.date.available | 2018-12-20T14:28:39Z | |
| Publication date | dc.date.issued | 1999 | |
| Cita de ítem | dc.identifier.citation | Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, Volumen 122, Issue 1, 2018, Pages 27-31 | |
| Identifier | dc.identifier.issn | 07428413 | |
| Identifier | dc.identifier.other | 10.1016/S0742-8413(98)10069-5 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/156101 | |
| Abstract | dc.description.abstract | Several β-carboline (9H-pyrido-[3,4-b]-indole) alkaloids were evaluated for in vitro trypanosomicidal activity against Trypanosoma cruzi epimastigotes belonging to two different strains (Tulahuen and LQ) showing different sensitivity to nifurtimox. Important differences were observed in the susceptibility of the parasites to these natural substances, with the relatively nifurtimox-resistant LQ strain showing greater sensitivity to the β-carbolines. Respiratory chain inhibition appears to be a possible determinant of the trypanosomicidal activity of these compounds. | |
| Lenguage | dc.language.iso | en | |
| Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| Source | dc.source | Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology | |
| Keywords | dc.subject | β-carboline alkaloids | |
| Keywords | dc.subject | Harmaline | |
| Keywords | dc.subject | Harmane | |
| Keywords | dc.subject | Harmine | |
| Keywords | dc.subject | LQ strain | |
| Keywords | dc.subject | Parasiticidal drugs | |
| Keywords | dc.subject | Trypanosoma cruzi | |
| Keywords | dc.subject | Trypanosomicidal drugs | |
| Keywords | dc.subject | Trypanosomicidal effect | |
| Keywords | dc.subject | Tulahuen strain | |
| Título | dc.title | Effects of some β-carboline alkaloids on intact Trypanosoma cruzi epimastigotes | |
| Document type | dc.type | Artículo de revista | |
| Cataloguer | uchile.catalogador | SCOPUS | |
| Indexation | uchile.index | Artículo de publicación SCOPUS | |
| uchile.cosecha | uchile.cosecha | SI |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile