Microsomal and peroxisomal fatty acid oxidation in liver of rats with bile duct ligation and two-thirds hepatectomy
Author
dc.contributor.author
Orellana, Myriam
Author
dc.contributor.author
Avalos, Nicolas
Author
dc.contributor.author
Abarca, Montserrat
Author
dc.contributor.author
Valdés, Elena
Admission date
dc.date.accessioned
2018-12-20T14:32:18Z
Available date
dc.date.available
2018-12-20T14:32:18Z
Publication date
dc.date.issued
1997
Cita de ítem
dc.identifier.citation
Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, Volumen 116, Issue 1, 2018, Pages 33-37
Identifier
dc.identifier.issn
07428413
Identifier
dc.identifier.other
10.1016/S0742-8413(96)00139-9
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/156339
Abstract
dc.description.abstract
Microsomal cytochrome P450 and peroxisomal activity were studied in liver of rats 7 days after two-thirds hepatectomy or bile duct ligation (BDL). Both surgical models decreased the hepatic microsomal cytochrome P450 content, but only cholestasis, produced by BDL, decreased the microsomal metabolism of lauric acid and aminopyrine, peroxisomal fatty acid β-oxidation and catalase activity. The microsomal and peroxisomal activities responded in a coordinate way to cholestasis and two-thirds hepatectomy. These results suggest a cause effect relationship between the microsomal cytochrome P450 and peroxisomal activity.