Copper in infant nutrition: Safety of World Health Organization provisional guideline value for copper content of drinking water
Author
dc.contributor.author
Olivares, Manuel
Author
dc.contributor.author
Pizarro Aguirre, Fernando
Author
dc.contributor.author
Speisky Cosoy, Hernán
Author
dc.contributor.author
Lönnerdal, Bo
Author
dc.contributor.author
Uauy Dagach-Imbarack, Ricardo
Admission date
dc.date.accessioned
2018-12-20T14:32:22Z
Available date
dc.date.available
2018-12-20T14:32:22Z
Publication date
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1998
Cita de ítem
dc.identifier.citation
Journal of Pediatric Gastroenterology and Nutrition, Volumen 26, Issue 3, 2018, Pages 251-257
Identifier
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02772116
Identifier
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10.1097/00005176-199803000-00003
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/156364
Abstract
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Background: Copper is an essential nutrient for humans. Recently, a limit of 31.48 μmol/l (2 mg/l) was proposed by the World Health Organization as the provisional guideline value for copper content of drinking water. The objective of the study was to determine the tolerance of chronic exposure to drinking water with low or high copper content in infants. Methods: Healthy infants (n = 128) were randomly assigned to receive drinking water with less than 1.57 μmol/l (<0.1 mg/l) (n = 48) or 31.48 μmol/l (2 mg/l) of copper (n = 80) from 3 to 12 months of age. At 6, 9, and 12 months of age, serum concentrations of copper, ceruloplasmin, and superoxide dismutase; erythrocyte metallothionein; bilirubin; transminases; and γ-glutamyl transferase were measured. Results: Small differences in biochemical indexes of copper nutrition were observed between the groups, but there was no evidence of adverse or toxic effects. These findings may be explained by an adaptive response to the higher copper in
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