Dissociation between plasma and monocyte‐associated cytokines during sepsis
Author
dc.contributor.author
Munoz, Carlos
Author
dc.contributor.author
et, Benoit
Author
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Fitting, Catherine
Author
dc.contributor.author
Blériot, Jean‐Pierre ‐P
Author
dc.contributor.author
Jean‐Carlet,
Author
dc.contributor.author
Cavaillon, Jean‐Marc ‐M
Admission date
dc.date.accessioned
2018-12-20T14:34:13Z
Available date
dc.date.available
2018-12-20T14:34:13Z
Publication date
dc.date.issued
1991
Cita de ítem
dc.identifier.citation
European Journal of Immunology, Volumen 21, Issue 9, 2018, Pages 2177-2184
Identifier
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15214141
Identifier
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00142980
Identifier
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10.1002/eji.1830210928
Identifier
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https://repositorio.uchile.cl/handle/2250/156467
Abstract
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We report our investigations of circulating interleukin (IL) 1β, IL 6 and tumor necrosis factor (TNF)‐α, as well as cell‐associated IL 1α, IL 1β and TNF‐α in plasma and monocytes of 21 patients with sepsis syndrome and 6 patients with non‐septic shock. Longitudinal studies reveal that (a) the most frequent detectable plasma cytokines were TNF‐α and IL 6, (b) the presence and the kinetics of circulating cytokines were independent of one other, (c) detectable levels of cytokines could be found for a long period of time, and (d) significantly higher levels of IL 6 were found for non‐surviving patients. Because of the in vivo half‐life of cytokines and of the existence of numerous specific high‐affinity receptors, it is quite probable that detectable plasma cytokines represent the excess of produced mediators which have not been trapped by the target cells. TNF‐α (410 ± 65 pg/106 monocytes) and IL 1β (153 ± 60 pg/106 monocytes) were frequently found associated to monocyte lysates (88% and