The spectrum of liver and gastrointestinal disease seen in cholestasis of pregnancy
Author
dc.contributor.author
Reyes,
Admission date
dc.date.accessioned
2018-12-20T14:34:20Z
Available date
dc.date.available
2018-12-20T14:34:20Z
Publication date
dc.date.issued
1992
Cita de ítem
dc.identifier.citation
Gastroenterology Clinics of North America, Volumen 21, Issue 4, 2018, Pages 905-921
Identifier
dc.identifier.issn
08898553
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/156503
Abstract
dc.description.abstract
A mild form of intrahepatic cholestasis is an infrequent complication of pregnancy, with a spontaneous cure almost immediately after delivery and that often recurs in future pregnancies. Pruritus alters maternal well-being, and a subclinical steatorrhea may impair the patient's nutritional status; otherwise, it is a mild disease in the mother, and no maternal mortality has been attributed to it. In contrast, cholestasis of pregnancy is often identified as a risk of increased perinatal morbidity and mortality. The cause of cholestasis of pregnancy is unknown. A hereditary predisposition seems to induce in the maternal liver an abnormal reaction to female sex hormones, but some still unidentified environmental (possibly dietary) factor could also be involved in the pathogenesis of the disease. Pruritus, but not the biochemical alterations, can be alleviated by the use of cholestyramine, silymarin, or epomediol. Ursodeoxycholic acid has been beneficial in pruritus and in liver function te