Effects of flunixin and mefenamic acid on cardiac pacemaker cells. Structure-activity relationship and comparison with clonixin
Author
dc.contributor.author
Morales,
Author
dc.contributor.author
Salazar,
Author
dc.contributor.author
Paeile,
Admission date
dc.date.accessioned
2018-12-20T14:34:22Z
Available date
dc.date.available
2018-12-20T14:34:22Z
Publication date
dc.date.issued
1993
Cita de ítem
dc.identifier.citation
General Pharmacology, Volumen 24, Issue 3, 2018, Pages 775-780
Identifier
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03063623
Identifier
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10.1016/0306-3623(93)90245-S
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/156512
Abstract
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1. 1. The electrophysiological effects of flunixin and mefenamic acid, non-steroidal analgesics, on frog cardiac pacemaker cells, were studied by intracellular action potential recording. 2. 2. Results show that flunixin (Flx) between2 × 10-6 and 1 × 10-4 M, exerts a frequency, OS, APA and Vmax concentration-dependent decrease, similar to the effects of clonixin (Clx) reported elsewhere (Morales et al., Gen. Pharmac. 23, 515-521, 1992). 3. 3. At 2.5 × 10-4 M, Flx induces a complete cessation of the electrical activity of subsidiary pacemaker cells. 4. 4. Mefenamic acid (Mef), in spite of its structural similarity with Clx and Flx, induces no appreciable electrophysiological changes. 5. 5. Flx effects were partially reversed by increasing external calcium concentration and fully antagonized by BAY K-8644, a calcium L-type channel agonist. 6. 6. By comparing the structures of the three fenamates studied, it is suggested that the nitrogen of the heterocycle and the electron-donor capacity