The disposition of nifurtimox in the rat isolated perfused liver: effect of dose size
Author
dc.contributor.author
González‐Martin, Guillermo
Author
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Ponce, Graciela
Author
dc.contributor.author
Inostroza, Verónica
Author
dc.contributor.author
González, Mario
Author
dc.contributor.author
Paulos, Claudio
Author
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Guevara, Alfredo
Admission date
dc.date.accessioned
2018-12-20T14:34:22Z
Available date
dc.date.available
2018-12-20T14:34:22Z
Publication date
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1993
Cita de ítem
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Journal of Pharmacy and Pharmacology, Volumen 45, Issue 1, 2018, Pages 72-74
Identifier
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20427158
Identifier
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00223573
Identifier
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10.1111/j.2042-7158.1993.tb03684.x
Identifier
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https://repositorio.uchile.cl/handle/2250/156514
Abstract
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Abstract— The disposition of nifurtimox was studied in the rat isolated perfused liver using a recirculating system. The drug was administered as a bolus (5·0, 15·0 or 30·0 μg mL−1), and its disappearance was monitored by analysing perfusate samples. In all experiments perfusate disappearance was monoexponential, and no significant difference was found between the three doses for the elimination constant (0·016, 0·011 and 0·012 min−1, respectively), half‐life (46·6, 65·8 and 66·8 min, respectively), extraction rate (0·128, 0·091 and 0·099, respectively) and distribution volume (41·1, 47·3 and 30·7 mL g−1, respectively). At 30 μg mL−1 the hepatic clearance was lower than the other concentrations of nifurtimox (0·66, 0·51 and 0·34 mL min−1 g−1, respectively). Relatively little parent drug was recovered from the liver at the end of the perfusions. In summary, nifurtimox is cleared slowly from the rat isolated perfused liver, is poorly extracted by hepatocyte cells and is completely metabo