Sistema de flujo continuo no segmentado con deteccion polarografica para la determinacion de ranitidina en formas farmaceuticas y orina
Author
dc.contributor.author
Jaque-Olmedo, Pablo
Author
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Toral Ponce, María
Author
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Richter Duk, Pablo
Admission date
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2018-12-20T14:35:52Z
Available date
dc.date.available
2018-12-20T14:35:52Z
Publication date
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1998
Cita de ítem
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Boletin de la Sociedad Chilena de Quimica, Volumen 43, Issue 1, 2018, Pages 045-053
Identifier
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03661644
Identifier
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https://repositorio.uchile.cl/handle/2250/156605
Abstract
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In this work we developed a method by flow injection analysis for the determination of ranitidine in pharmaceutical forms and urine, using a polarographic flow through cell as detection system which has been designed recently in our laboratory. The method is based on the reduction of the group nitro of the drug to the hydroxylamine derivative by applying a potential of -1.40 V vs mercury pool electrode. It was found a determination range of 2.38×10 -5 -1.0×10 -3 M ranitidine, with a detection limit of 7.15×10 -6 M. The relative standard deviation (n = 11) for a concentration level of 1.0×10 -4 M was 2.1%, which is comparable with the obtained, by the manual methodology. The accuracy of the method was evaluated by comparison of the results with those obtained by d.c. polarography and UV spectrophotometry and the results were quite comparable.