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pH and P.E.G.-400 effects on flucloxacillin absorption

Authordc.contributor.authorNúñez Vergara, Luis 
Authordc.contributor.authorLemus, I. R. 
Authordc.contributor.authorSquella Serrano, Juan
Admission datedc.date.accessioned2018-12-20T15:04:34Z
Available datedc.date.available2018-12-20T15:04:34Z
Publication datedc.date.issued1988
Cita de ítemdc.identifier.citationGeneral Pharmacology, Volumen 19, Issue 3, 2018, Pages 447-449
Identifierdc.identifier.issn03063623
Identifierdc.identifier.other10.1016/0306-3623(88)90045-6
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/157549
Abstractdc.description.abstract1. 1. Intestinal clearances of flucloxacillin significantly decrease with the increase of pH, concomitantly with a decrease of the percent absorbed at 60 min. 2. 2. The apparent rate constants for unionized (Ku) and ionized species are 0.173 min-1 and 0.017 min-1 respectively. 3. 3. The addition of P.E.G.-400 at different concentrations significantly enhanced intestinal clearances of flucloxacillin parallel to an increase of net water flux from the lumen of the small intestine. © 1988.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceGeneral Pharmacology
Keywordsdc.subjectPharmacology
Títulodc.titlepH and P.E.G.-400 effects on flucloxacillin absorption
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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