pH and P.E.G.-400 effects on flucloxacillin absorption
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1988Metadata
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Núñez Vergara, Luis
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pH and P.E.G.-400 effects on flucloxacillin absorption
Abstract
1. 1. Intestinal clearances of flucloxacillin significantly decrease with the increase of pH, concomitantly with a decrease of the percent absorbed at 60 min. 2. 2. The apparent rate constants for unionized (Ku) and ionized species are 0.173 min-1 and 0.017 min-1 respectively. 3. 3. The addition of P.E.G.-400 at different concentrations significantly enhanced intestinal clearances of flucloxacillin parallel to an increase of net water flux from the lumen of the small intestine. © 1988.
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URI: https://repositorio.uchile.cl/handle/2250/157549
DOI: 10.1016/0306-3623(88)90045-6
ISSN: 03063623
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General Pharmacology, Volumen 19, Issue 3, 2018, Pages 447-449
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