Analgesic action of clonixin, nifedipine and morphine using the formalin test

Abstract

1. The analgesic effect of C1X, nifedipine, metamizol, indoprofen and morphine in the pain induced by formalin injection (formalin test) was studied. 2. Attempts to demonstrate tolerance to C1X were unsuccessful. 3. In the analgesic test nifedipine and morphine are approximately 10 times more potent than C1X. 4. The present results suggest that the analgesic action of C1X is not mediated by μ1, δ or κ-opioid receptors and the anti-nociceptive effect of nifedipine may be associated with the blockade of the transmembrane inward movements of calcium.