Design of a prolonged release matrix system based on chitosan of chilean production

Abstract

The objectives of this work were to establish the utility of chitosan of Chilean production, as an excipient suitable for producing a prolonged-release hydrophilic matrix, and to compare two matrix systems, one with chitosan (Q) and the other with the mixture chitosan-alginate (Q/A).The formulations (Q/A) produced a more prolonged drug release than formulations (Q). Formulations B (Q 20%), C (Q 30%), and D (Q/A 10%) showed a mechanism of release controlled by fickian diffusion. Formulations E (Q/A 20%) and F (Q/A 30%) showed a non-fickian diffusion. The thermodynamic activation parameters calculated for formulations C and D showed similar dG values.

The objectives of this work were to establish the utility of chitosan of Chilean production, as an excipient suitable for producing a prolonged-release hydrophilic matrix, and to compare two matrix systems, one with chitosan (Q) and the other with the mixture chitosan-alginate (Q/A). The formulations (Q/A) produced a more prolonged drug release than formulations (Q). Formulations B (Q 20%), C (Q 30%). and D (Q/A 10%) showed a mechanism of release controlled by fickian diffusion. Formulations E (Q/A 20%) and F (Q/A 30%) showed a non-fickian diffusion. The thermodynamic activation parameters calculated for formulations C and D showed similar dG values.