Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
Author
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Ocaranza, Maria Paz
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Moya, Jackeline
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Barrientos, Victor
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Alzamora, Rodrigo
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Hevia, Daniel
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Morales, Cristobal
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Pinto, Melissa
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Escudero, Nicolás
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García Nannig, Lorena
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Novoa, Ulises
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Ayala, Pedro
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Díaz Araya, Guillermo
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Godoy, Ivan
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Chiong Lay, Mario
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Lavandero González, Sergio
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Jalil Milad, Jorge
Admission date
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2018-12-20T15:10:56Z
Available date
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2018-12-20T15:10:56Z
Publication date
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2014
Cita de ítem
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Journal of Hypertension, Volumen 32, Issue 4, 2018, Pages 771-783
Identifier
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14735598
Identifier
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02636352
Identifier
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10.1097/HJH.0000000000000094
Identifier
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https://repositorio.uchile.cl/handle/2250/158312
Abstract
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BACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: In this study, we evaluated whether angiotensin-(1-9) decreases hypertension and reverses experimental cardiovascular damage in the rat. METHODS AND RESULTS:: Angiotensin-(1-9) (600 ng/kg per min for 2 weeks) reduced already-established hypertension in rats with early high blood pressure induced by angiotensin II infusion or renal artery clipping. Angiotensin-(1-9) also improved cardiac (assessed by echocardiography) and endothelial function in small-diameter mesenteric arteries, cardiac and aortic wall hypertrophy, fibrosis, oxidative stress, collagen and transforming growth factor type β - 1 protein expression (assessed by western blot). The beneficial effect of angiotensin-(1-9) was blunted by coadministration of the angiotensin type 2(AT2) receptor blocker PD123319
Ocaranza, María Paz; Palomera, Cristián; Román, Maritza; Bargetto, Jorge; Lavandero González, Sergio; Jalil Milad, Jorge(PERGAMON-ELSEVIER SCIENCE LTD, 2006-02-28)
To determine circulating angiotensin-(1-7) [Ang-(1,7)] levels in rats with different angiotensin converting enzyme (ACE) genotypes and to evaluate the effect of hypertension on levels of this heptapeptide, plasma levels ...
Westermeier, Francisco; Bustamante, Mario; Pavez, Mario; García Nannig, Lorena; Chiong Lay, Mario; Ocaranza, María Paz; Lavandero González, Sergio(Elsevier, 2015)
Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic ...
The aim of this study was to estimate the prevalence of the different alleles of the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and associated plasma ACE activity, as well as cardiac ...