Show simple item record

Authordc.contributor.authorOcaranza, Maria Paz 
Authordc.contributor.authorMoya, Jackeline 
Authordc.contributor.authorBarrientos, Victor 
Authordc.contributor.authorAlzamora, Rodrigo 
Authordc.contributor.authorHevia, Daniel 
Authordc.contributor.authorMorales, Cristobal 
Authordc.contributor.authorPinto, Melissa 
Authordc.contributor.authorEscudero, Nicolás 
Authordc.contributor.authorGarcía Nannig, Lorena 
Authordc.contributor.authorNovoa, Ulises 
Authordc.contributor.authorAyala, Pedro 
Authordc.contributor.authorDíaz Araya, Guillermo 
Authordc.contributor.authorGodoy, Ivan 
Authordc.contributor.authorChiong Lay, Mario 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorJalil Milad, Jorge 
Admission datedc.date.accessioned2018-12-20T15:10:56Z
Available datedc.date.available2018-12-20T15:10:56Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationJournal of Hypertension, Volumen 32, Issue 4, 2018, Pages 771-783
Identifierdc.identifier.issn14735598
Identifierdc.identifier.issn02636352
Identifierdc.identifier.other10.1097/HJH.0000000000000094
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158312
Abstractdc.description.abstractBACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: In this study, we evaluated whether angiotensin-(1-9) decreases hypertension and reverses experimental cardiovascular damage in the rat. METHODS AND RESULTS:: Angiotensin-(1-9) (600 ng/kg per min for 2 weeks) reduced already-established hypertension in rats with early high blood pressure induced by angiotensin II infusion or renal artery clipping. Angiotensin-(1-9) also improved cardiac (assessed by echocardiography) and endothelial function in small-diameter mesenteric arteries, cardiac and aortic wall hypertrophy, fibrosis, oxidative stress, collagen and transforming growth factor type β - 1 protein expression (assessed by western blot). The beneficial effect of angiotensin-(1-9) was blunted by coadministration of the angiotensin type 2(AT2) receptor blocker PD123319
Lenguagedc.language.isoen
Publisherdc.publisherLippincott Williams and Wilkins
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Hypertension
Keywordsdc.subjectAngiotensin II
Keywordsdc.subjectAngiotensin-(1'9)
Keywordsdc.subjectCardiovascular remodeling
Keywordsdc.subjectFibrosis
Keywordsdc.subjectHypertension
Keywordsdc.subjectHypertrophy
Keywordsdc.subjectRenin'angiotensin system
Títulodc.titleAngiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile