A convenient synthesis of benzo[g]pyrrolo[3,2-c]quinoline-6,11-diones
Author
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Tapia, Ricardo
Author
dc.contributor.author
López, Claudio
Author
dc.contributor.author
Morello Casté, Antonio
Author
dc.contributor.author
Maya Arango, Juan
Author
dc.contributor.author
Valderrama, Jaime
Admission date
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2018-12-20T15:20:42Z
Available date
dc.date.available
2018-12-20T15:20:42Z
Publication date
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2005
Cita de ítem
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Synthesis. 2005(6): 903-906.
Identifier
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00397881
Identifier
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10.1055/s-2005-861802
Identifier
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https://repositorio.uchile.cl/handle/2250/158875
Abstract
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The synthesis of a new class of angular tetracyclic quinones is described. Our strategy involves Diels-Alder reaction of pyrroloquinolinequinone 9, generated in situ from pyrroloquinoline 8, and dienes. The required pyrroloquinoline 8 was prepared in four steps from commercially available compounds. All compounds were tested for trypanocidal activity in vitro against Trypanosoma cruzi epimastigotes.