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Biblioteca Digital - Universidad de Chile
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HTLV-I retrovirus in Chile: study on 140 neurological patients

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1990
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Cartier Rovirosa, Luis
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HTLV-I retrovirus in Chile: study on 140 neurological patients
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Author
  • Cartier Rovirosa, Luis;
  • Araya, F.;
  • Castillo, José Luis;
  • Verdugo Latorre, Renato;
  • Mora, C.;
  • Gajdusek, D. Carleton;
  • Gibbs, C.;
Abstract
We screened 140 patients with different neurological diseases for the presence of anti HTLV-1 virus antibodies. ELISA test confirmed with Western Blot analysis was performed in CSF and blood. Positive findings were obtained in 23 out of 52 patients with progressive spastic paraparesis (44%). All patients with multiple sclerosis, polymyositis, amyotrophic lateral sclerosis or chronic polyneuropathy were negative. Patients with progressive spastic paraparesis and positive HTLV-1 antibodies were most commonly women (78%) and middle aged (mean 46 years old), with a history of surgical interventions (70%) or blood transfusion (35%). A slowly progressive spastic paraparesis with asymmetric onset and minimal sensory complaints was observed in some cases. Mononuclear pleocytosis in the CSF was observed in 35% with an increased IgG index in 88%. A delayed latency and low amplitude of somatosensory evoked potentials was observed in 89% of patients.
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URI: https://repositorio.uchile.cl/handle/2250/159671
ISSN: 00349887
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Revista medica de Chile, Volumen 118, Issue 6, 1990, Pages 622-628
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