The local anesthetic activity of proadifen HCl (2-diethylaminoethyl-α,α-diphenylvalerate, HCl)
Author
dc.contributor.author
Guerrero, S.
Author
dc.contributor.author
Montoya, G.
Author
dc.contributor.author
Molgó,
Admission date
dc.date.accessioned
2019-01-29T13:47:56Z
Available date
dc.date.available
2019-01-29T13:47:56Z
Publication date
dc.date.issued
1970
Cita de ítem
dc.identifier.citation
European Journal of Pharmacology, Volumen 10, Issue 1, 1970, Pages 131-134
Identifier
dc.identifier.issn
00142999
Identifier
dc.identifier.other
10.1016/0014-2999(70)90169-X
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/159864
Abstract
dc.description.abstract
The direct blocking effect of proadifen on nerve conduction and surface receptors was compared with that of lidocaine and procaine. Proadifen was active as a local anesthetic at significantly lower concentrations than the other two drugs in the desheathed sciatic nerve preparation as well as in the rabbit cornea. Its potency in the isolated nerve is 7.85 times that of procaine.