The local anesthetic activity of proadifen HCl (2-diethylaminoethyl-α,α-diphenylvalerate, HCl)
The direct blocking effect of proadifen on nerve conduction and surface receptors was compared with that of lidocaine and procaine. Proadifen was active as a local anesthetic at significantly lower concentrations than the other two drugs in the desheathed sciatic nerve preparation as well as in the rabbit cornea. Its potency in the isolated nerve is 7.85 times that of procaine.
Artículo de publicación SCOPUS
Quote ItemEuropean Journal of Pharmacology, Volumen 10, Issue 1, 1970, Pages 131-134