Effect of (+)-cyanidanol-3 on the changes in liver glutathione content and lipoperoxidation induced by acute ethanol administration in the rat
Acute ethanol administration to rats fasted overnight resulted in a significant decrease in the content of glutathione (GSH) of the liver concomitantly with a partial increase in oxidized glutathione levels, representing a net 38% decrease in total GSH equivalents. In these conditions, liver lipoperoxidation is significantly enhanced. Treatment with (+)-cyanidanol-3 prior to ethanol ingestion was able to reduce by 80% the ethanol-induced depletion in total GSH equivalents and to completely abolish lipoperoxidation. These results indicate that (+)-cyanidanol-3 has a protective effect on the changes in liver GSH levels and lipoperoxidation induced by ethanol, probably related to its scavenging action exerted on free radicals.
Artículo de publicación SCOPUS
Quote ItemPharmacology, Volumen 22, Issue 6, 2018, Pages 343-348