Pharmacokinetics of ethynyloestradiol in women from different populations
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1981Metadata
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Fotherby, K.
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Pharmacokinetics of ethynyloestradiol in women from different populations
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The pharmacokinetics of a dose of 50μg ethynyloestradiol administered orally was studied in fourteen centres. Absorption was rapid and the highest serum concentrations of total ethynyloestradiol were found in most subjects at 1 h and by 24 h concentrations were less than 250 pg/ml. Calculation of the half-lives for absorption, distribution and elimination showed wide variations between subjects, the half-life of elimination varying from 2.5 h to more than 30 h. Bioavailability as measured by the area under the serum ethynyloestradiol concentration-time curve also showed more than a ten-fold variation. Intra-centre differences in the various parameters measured were as large as the inter-centre differences. © 1981.
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URI: https://repositorio.uchile.cl/handle/2250/160411
DOI: 10.1016/0010-7824(81)90076-7
ISSN: 00107824
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Contraception, Volumen 23, Issue 5, 2018, Pages 487-496
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