Lindane-induced oxidative stress. II. Time course of changes in hepatic glutathione status
| Author | dc.contributor.author | Barros, Silvia B.M. | |
| Author | dc.contributor.author | Videla Cabrera, Luis | |
| Author | dc.contributor.author | Simizu, Kiyoko | |
| Author | dc.contributor.author | Van Halsema, Leonardo | |
| Author | dc.contributor.author | Junqueira, Virginia B.C. | |
| Admission date | dc.date.accessioned | 2019-01-29T14:48:46Z | |
| Available date | dc.date.available | 2019-01-29T14:48:46Z | |
| Publication date | dc.date.issued | 1988 | |
| Cita de ítem | dc.identifier.citation | Xenobiotica, Volumen 18, Issue 11, 2018, Pages 1305-1310 | |
| Identifier | dc.identifier.issn | 00498254 | |
| Identifier | dc.identifier.other | 10.3109/00498258809042254 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/160797 | |
| Abstract | dc.description.abstract | 1. Four hours after treatment of rats with lindane (60 mg/kg), hepatic GSH content was decreased (22% and GSSG was increased (20% while biliary concentration and excretion of both GSH and GSSG and bile flow were diminished. These changes coincide with the onset of hepatic lipid peroxidation. 2. The changes induced by lindane at 4 h disappeared at 6 h after treatment, but liver GSSG content (91% biliary GSSG excretion (133% and bile flow (42% were enhanced at 24 h. 3. The data indicate that lindane treatment elicits marked changes in hepatocyte glutathione status, with a decrease in the GSH/GSSG ratio at early (2-4 h) and late (24 h) periods of poisoning. © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. | |
| Lenguage | dc.language.iso | en | |
| Publisher | dc.publisher | Informa Healthcare | |
| Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| Source | dc.source | Xenobiotica | |
| Keywords | dc.subject | Biochemistry | |
| Keywords | dc.subject | Toxicology | |
| Keywords | dc.subject | Pharmacology | |
| Keywords | dc.subject | Health, Toxicology and Mutagenesis | |
| Título | dc.title | Lindane-induced oxidative stress. II. Time course of changes in hepatic glutathione status | |
| Document type | dc.type | Artículo de revista | |
| Cataloguer | uchile.catalogador | SCOPUS | |
| Indexation | uchile.index | Artículo de publicación SCOPUS | |
| uchile.cosecha | uchile.cosecha | SI |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile