Lindane-induced oxidative stress. II. Time course of changes in hepatic glutathione status

Abstract

1. Four hours after treatment of rats with lindane (60 mg/kg), hepatic GSH content was decreased (22% and GSSG was increased (20% while biliary concentration and excretion of both GSH and GSSG and bile flow were diminished. These changes coincide with the onset of hepatic lipid peroxidation. 2. The changes induced by lindane at 4 h disappeared at 6 h after treatment, but liver GSSG content (91% biliary GSSG excretion (133% and bile flow (42% were enhanced at 24 h. 3. The data indicate that lindane treatment elicits marked changes in hepatocyte glutathione status, with a decrease in the GSH/GSSG ratio at early (2-4 h) and late (24 h) periods of poisoning. © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.