A decade of antiretroviral therapy: A profile of patients with 10 years of highly effective triple therapy Una década de terapia anti-retroviral: Perfil de pacientes con 10 años de triterapia de alta efectividad

Abstract

Introduction: Highly effective antiretroviral triple therapy (TAR 3) has led to a significant increase in survival of patients (pts) infected with human immunodeficiency virus. In 1999 it was started in the Chilean public health system, including Arriarán Foundation (FA) access to TAR 3, reaching full coverage since 2003. By October 31, 2009 124 pts had reached 10 years of uninterrupted TAR 3 in FA. Objective: To describe and analyze the profile of pts, their therapeutic regimen (s) and clinical outcomes during 10 years of TAR 3. Methods: Retrospective descriptive study. We reviewed the records of pts who had reached 10 years of uninterrupted TAR 3 in FA. Demographic data, baseline and virological staging at start of TAR 3, comorbidities and complications were recorded. Drug regimens used were analyzed, as well as toxicity, virological and immunological outcomes, frequency and reasons for change in therapy. Complications were classified as opportunistic and not opportunistic during thi