Cardiac and pulmonary oxidative stress in rats exposed to realistic emissions of source aerosols
Artículo

Open/ Download
Access note
Acceso Abierto
Publication date
2011Metadata
Show full item record
Cómo citar
Lemos, Miriam
Cómo citar
Cardiac and pulmonary oxidative stress in rats exposed to realistic emissions of source aerosols
Author
Abstract
In vivo chemiluminescence (CL) is a measure of reactive oxygen species in tissues. CL was used to assess pulmonary and cardiac responses to inhaled aerosols derived from aged emissions of three coal-fired power plants in the USA. SpragueDawley rats were exposed to either filtered air or: (1) primary emissions (P); (2) ozone oxidized emissions (PO); (3) oxidized emissions + secondary organic aerosol (SOA) (POS); (4) neutralized oxidized emissions + SOA (PONS); and (5) control scenarios: oxidized emissions + SOA in the absence of primary particles (OS), oxidized emissions alone (O), and SOA alone (S). Immediately after 6 hours of exposure, CL in the lung and heart was measured. Tissues were also assayed for thiobarbituric acid reactive substances (TBARS). Exposure to P or PO aerosols led to no changes compared to filtered air in lung or heart CL at any individual plant or when all data were combined. POS caused significant increases in lung CL and TBARS at only one plant, and not in comb
Indexation
Artículo de publicación SCOPUS
Identifier
URI: https://repositorio.uchile.cl/handle/2250/161810
DOI: 10.3109/08958378.2011.601433
ISSN: 08958378
10917691
Quote Item
Inhalation Toxicology, Volumen 23, Issue SUPPL. 2, 2018, Pages 75-83
Collections