Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)
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Barnhart, Kurt
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Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant)
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Objective: To evaluate a nomegestrol acetate subdermal contraceptive implant's (Uniplant; Thermex, Monaco) effect on the hypothalamus-pituitary- ovarian axis. Design: A prospective clinical trial. Setting: San Borja- Arriaran Clinical Hospital, University of Chile, School of Medicine. Patient(s): Normally cycling healthy women. Intervention(s): Insertion of Uniplant. Main Outcome Measure(s): Luteinizing hormone pulse and endocrine profiles were assessed before, 48 hours after insertion, and after prolonged use of the implant. Result(s): Anovulation was noted in 100% of users in the first month. Seventy percent of subjects demonstrated follicular development with the absence of ovulation and an endocrine profile similar to the follicular phase: (LH pulse/8 hours 6.85 ± 0.67, LH amplitude 3.54 ± 0.65 mIU/mL (conversion factor to SI unit, 1.00), and E2 193 ± 29.4 pg/mL (conversion factor to SI unit, 3.67), whereas 30% demonstrated no follicular activity with an endocrine profile similar t
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URI: https://repositorio.uchile.cl/handle/2250/162781
DOI: 10.1016/S0015-0282(97)81906-1
ISSN: 00150282
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Fertility and Sterility, Volumen 67, Issue 2, 2018, Pages 250-255
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