Ultrastructure of human Sertoli cells at early gonad embryogenesis Ultrastructure des cellules de Sertoli humaines aux stades embryonnaires precoces de la differenciation gonadique
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Makabe, S.
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Ultrastructure of human Sertoli cells at early gonad embryogenesis Ultrastructure des cellules de Sertoli humaines aux stades embryonnaires precoces de la differenciation gonadique
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The morphofunctional development of Sertoli cells defines the testicular differentiation. These somatic cells are mostly of mesonephric origin and can be first recognized in 7 week-old embryos altogether with the formation of testicular cords. The latter organize as primordial germ cells surrounded by pre-Sertoli cells. Due to the great synthetic activity of pre-Sertoli cells the rough endoplasmic reticulum develops. The basal lamina of the cords becomes distinguishable at 7 to 8 weeks of development. Either prespermatogonia and pre-Sertoli cells actively proliferate but the latter greatly outnumber prespermatogonia. Many interdigitations and cytoplasmic processes are observed between neighboring pre-Sertoli cells. Due to the proliferative activity a sort of compartmentalization is established inside the cords in which pre-Sertoli cells tend to localize closer to the basal membrane embracing the prespermatogonia with long and thin cytoplasmic processes. One of the main features typical
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URI: https://repositorio.uchile.cl/handle/2250/163317
DOI: 10.1007/BF03034550
ISSN: 11662654
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Andrologie, Volumen 7, Issue 3, 2018, Pages 327-335
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