Immunogenicity and reactogenicity of a combined hepatitis A and B vaccine in healthy Chilean subjects
Author
dc.contributor.author
Prado, V.
Author
dc.contributor.author
Riedemann, S.
Author
dc.contributor.author
Ibarra, H.
Author
dc.contributor.author
Potin, M.
Admission date
dc.date.accessioned
2019-01-29T17:50:59Z
Available date
dc.date.available
2019-01-29T17:50:59Z
Publication date
dc.date.issued
2002
Cita de ítem
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International Journal of Infectious Diseases, Volumen 6, Issue 2, 2018, Pages 129-133
Identifier
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12019712
Identifier
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10.1016/S1201-9712(02)90074-3
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/163474
Abstract
dc.description.abstract
Objectives: A combination vaccine against hepatitis A and B provides the opportunity for simultaneous protection against both diseases with a single vaccine. This clinical study investigated the reactogenicity and immunogenicity of a combined hepatitis A and B vaccine (Twinrix, GlaxoSmithKline Biologicals, Rixensart, Belgium) in healthy Chilean adults between 18 and 40 years of age. Methods: In total, 345 healthy, seronegative health care workers were enrolled and randomized to three groups who received one of three lots of Twinrix on a 0-, 1- and 6-month schedules. Blood samples were screened 1 month after each dose for anti-HAV and anti-HBs antibodies. Reactogenicity after each dose was assessed using diary cards. Results: The nature and incidence of symptoms were similar to those reported for other Twinrix studies. Very few symptoms were scored as severe. Upon completion of the vaccination, all subjects had anti-HAV antibodies with titers >6000 mIU/mL, and all but one were protected