Immunogenicity and reactogenicity of a combined hepatitis A and B vaccine in healthy Chilean subjects
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Prado, V.
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Immunogenicity and reactogenicity of a combined hepatitis A and B vaccine in healthy Chilean subjects
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Objectives: A combination vaccine against hepatitis A and B provides the opportunity for simultaneous protection against both diseases with a single vaccine. This clinical study investigated the reactogenicity and immunogenicity of a combined hepatitis A and B vaccine (Twinrix, GlaxoSmithKline Biologicals, Rixensart, Belgium) in healthy Chilean adults between 18 and 40 years of age. Methods: In total, 345 healthy, seronegative health care workers were enrolled and randomized to three groups who received one of three lots of Twinrix on a 0-, 1- and 6-month schedules. Blood samples were screened 1 month after each dose for anti-HAV and anti-HBs antibodies. Reactogenicity after each dose was assessed using diary cards. Results: The nature and incidence of symptoms were similar to those reported for other Twinrix studies. Very few symptoms were scored as severe. Upon completion of the vaccination, all subjects had anti-HAV antibodies with titers >6000 mIU/mL, and all but one were protected
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URI: https://repositorio.uchile.cl/handle/2250/163474
DOI: 10.1016/S1201-9712(02)90074-3
ISSN: 12019712
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International Journal of Infectious Diseases, Volumen 6, Issue 2, 2018, Pages 129-133
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