Carbachol interactions with nonsteroidal anti-inflammatory drugs
Author
dc.contributor.author
Miranda, Daniela
Author
dc.contributor.author
Sierralta, Fernando
Author
dc.contributor.author
Pinardi,
Admission date
dc.date.accessioned
2019-01-29T17:51:52Z
Available date
dc.date.available
2019-01-29T17:51:52Z
Publication date
dc.date.issued
2002
Cita de ítem
dc.identifier.citation
Canadian Journal of Physiology and Pharmacology, Volumen 80, Issue 12, 2018, Pages 1173-1179
Identifier
dc.identifier.issn
00084212
Identifier
dc.identifier.other
10.1139/y02-145
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/163593
Abstract
dc.description.abstract
The inhibition of cyclooxygenase enzymes by nonsteroidal anti-inflammatory drugs (NSAIDs) does not completely explain the antinociceptive efficacy of these agents. It is known that cholinergic agonists are antinociceptive, and this study evaluates the interactions between carbachol and some NSAIDs. Antinociceptive activity was evaluated in mice by the acetic acid writhing test. Dose-response curves were constructed for NSAIDs and carbachol, administered either intraperitoncally (i.p.) or intrathecally (i.t.). The interactions of carbachol with NSAIDs were evaluated by isobolographic analysis after the simultaneous administration of fixed proportions of carbachol with each NSAID. All of the drugs were more potent after spinal than after systemic administration. The combinations of NSAIDs and carbachol administered i.p. were supra-additive; however, the i.t. combinations were only additive. Isobolographic analysis of the coadministration of NSAIDs and carbachol and the fact that atropine