Carbachol interactions with nonsteroidal anti-inflammatory drugs
Artículo

Open/ Download
Publication date
2002Metadata
Show full item record
Cómo citar
Miranda, Daniela
Cómo citar
Carbachol interactions with nonsteroidal anti-inflammatory drugs
Author
Abstract
The inhibition of cyclooxygenase enzymes by nonsteroidal anti-inflammatory drugs (NSAIDs) does not completely explain the antinociceptive efficacy of these agents. It is known that cholinergic agonists are antinociceptive, and this study evaluates the interactions between carbachol and some NSAIDs. Antinociceptive activity was evaluated in mice by the acetic acid writhing test. Dose-response curves were constructed for NSAIDs and carbachol, administered either intraperitoncally (i.p.) or intrathecally (i.t.). The interactions of carbachol with NSAIDs were evaluated by isobolographic analysis after the simultaneous administration of fixed proportions of carbachol with each NSAID. All of the drugs were more potent after spinal than after systemic administration. The combinations of NSAIDs and carbachol administered i.p. were supra-additive; however, the i.t. combinations were only additive. Isobolographic analysis of the coadministration of NSAIDs and carbachol and the fact that atropine
Indexation
Artículo de publicación SCOPUS
Identifier
URI: https://repositorio.uchile.cl/handle/2250/163593
DOI: 10.1139/y02-145
ISSN: 00084212
Quote Item
Canadian Journal of Physiology and Pharmacology, Volumen 80, Issue 12, 2018, Pages 1173-1179
Collections