Effects of chronic simulated hypobaric hypoxia on mouse spermatogenesis
Author
dc.contributor.author
Bustos Obregón, Eduardo
Author
dc.contributor.author
Esveile, Christian
Author
dc.contributor.author
Contreras, Julio
Author
dc.contributor.author
Maurer, Inge
Author
dc.contributor.author
Sarabia, Luis
Admission date
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2019-03-11T12:53:14Z
Available date
dc.date.available
2019-03-11T12:53:14Z
Publication date
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2006
Cita de ítem
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International Journal of Morphology, Volumen 24, Issue 3, 2018, Pages 481-488
Identifier
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07179502
Identifier
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07179367
Identifier
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10.4067/S0717-95022006000400030
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/164253
Abstract
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Reduction of O2 delivery to tissues damage them, including the seminiferous epithelium. Recently, population working in high altitude has increased, so that the study of hypobaric hypoxia on spermatogenesis becomes of interest. In this study we used two groups of male, sexually mature mice Control (C) (540 meters above sea level (masl)) and chronic simulated hypobaric hypoxia (CSHH) (4,600 masl) exposed during 8, 16, 24 or 33 days. Hematocrit; reticulocytosis; testicular, epididymal and seminal vesicle weight; seminiferous epithelium height, tubular diameter, sperm count and morphology and testicular parenchyme and spermatozoa membranes lipoperoxidation were measured. Weight of testis, epididymis and seminal vesicle were reduced but they recuperate at 33 days. Tubular diameter and epithelial height are reduced, subsequently they tend to increase without returning to normal values. The count and sperm morphology fluctuate along the exposure time. Lipoperoxidation levels of spermatozoa a