Effects of chronic simulated hypobaric hypoxia on mouse spermatogenesis
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Bustos Obregón, Eduardo
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Effects of chronic simulated hypobaric hypoxia on mouse spermatogenesis
Abstract
Reduction of O2 delivery to tissues damage them, including the seminiferous epithelium. Recently, population working in high altitude has increased, so that the study of hypobaric hypoxia on spermatogenesis becomes of interest. In this study we used two groups of male, sexually mature mice Control (C) (540 meters above sea level (masl)) and chronic simulated hypobaric hypoxia (CSHH) (4,600 masl) exposed during 8, 16, 24 or 33 days. Hematocrit; reticulocytosis; testicular, epididymal and seminal vesicle weight; seminiferous epithelium height, tubular diameter, sperm count and morphology and testicular parenchyme and spermatozoa membranes lipoperoxidation were measured. Weight of testis, epididymis and seminal vesicle were reduced but they recuperate at 33 days. Tubular diameter and epithelial height are reduced, subsequently they tend to increase without returning to normal values. The count and sperm morphology fluctuate along the exposure time. Lipoperoxidation levels of spermatozoa a
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Artículo de publicación SCOPUS
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URI: https://repositorio.uchile.cl/handle/2250/164253
DOI: 10.4067/S0717-95022006000400030
ISSN: 07179502
07179367
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International Journal of Morphology, Volumen 24, Issue 3, 2018, Pages 481-488
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