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Authordc.contributor.authorMoraga, Francisco 
Authordc.contributor.authorTroncoso, Rodrigo 
Authordc.contributor.authorMellado, Rosemarie 
Authordc.contributor.authorDíaz Araya, Guillermo 
Authordc.contributor.authorVukasovic, José Luis 
Authordc.contributor.authorGreig, Douglas 
Authordc.contributor.authorPérez, Osvaldo 
Authordc.contributor.authorGarcía Nannig, Lorena 
Authordc.contributor.authorRoldán, Juan 
Authordc.contributor.authorOcaranza, María Paz 
Authordc.contributor.authorJalil Milad, Jorge 
Authordc.contributor.authorChiong Lay, Mario 
Authordc.contributor.authorCastro, Pablo 
Cita de ítemdc.identifier.citationRevista Medica de Chile, Volumen 136, Issue 11, 2018, Pages 1371-1380
Abstractdc.description.abstractBackground: ß adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostasis. Among these, ß1 and ß2 AR regulate cardiac contractility and frequency and are important pharmacological targets. Aim: To evaluate genotype and gene-gene interaction between ß1-AR Arg389Gly and ß2-AR Arg16Gly, Gln27Glu and Thr164Ile polymorphisms, as risk factors for HF. Material and methods: Eighty chronic HF patients and eighty-eight controls matched by age and sex were genotyped for ß1-AR Arg389Gly, ß2-AR Arg16Gly, Gln27Glu and Thr164Ile polymorphisms. Results: The presence of ß2-AR Glu allele was a risk predictor for HF (odds ratio (OR) =2.81; 95% confidence intervals (CI) =1.49-5.31). Interactions that increased the risk for HF were found in patients carrying at least one of the ß2-AR Glu and ß2-AR Gly allele (OR =3.81; 95% CI =1.50-0.70) and ß2-AR Glu and ß1-AR Gly allele combination (OR =5.51; 95% CI =2.19-13.86). Furthermore, the frequency of ß2-AR Glu allele w
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceRevista Medica de Chile
Keywordsdc.subjectHeart failure
Keywordsdc.subjectReceptors, adrenergic
Títulodc.titleInteractions between ß 1 and ß 2 adrenergic receptor polymorphisms as risk factors for chronic heart failure Interacción entre los polimorfismos del receptor ß 1 y ß 2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile