Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus
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Larrañaga, Carmen L.
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Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus
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Background: Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory infection in infants. The immune response plays a leading role in the severity of the disease. We hypothesized that severe RSV disease is associated with an impaired immune response characterized by low circulating T lymphocytes and plasma cytokine concentrations. Methods: We evaluate the in vivo immune responses of previously healthy infants with their first proven RSV-acute lower respiratory infection that required hospitalization. According to the clinical severity, defined by using a strict scoring system, the in vivo immune response was compared through the analysis of plasma cytokine values and the phenotyping of peripheral blood lymphocyte and natural killer (NK) cells. Results: Absolute blood cell counts of CD4+, CD8+, and CD19+ lymphocytes and NK cells were lower in subjects with RSV than in control infants. Lowest cell counts were observed in more severe RSV-infected infants. Significant
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URI: https://repositorio.uchile.cl/handle/2250/164850
DOI: 10.1097/INF.0b013e3181a3ea71
ISSN: 15320987
08913668
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Pediatric Infectious Disease Journal, Volumen 28, Issue 10, 2018, Pages 867-873
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