Comparison of the antidepressant sertraline on differential depression-like behaviors elicited by restraint stress and repeated corticosterone administration

Abstract

Depressive disorder involves emotional, cognitive, autonomic and endocrine alterations and also evidences support the role of stress in the development of this disorder. Because the hypothalamic-pituitary-adrenal axis is involved in the stress response with a concomitant rise in plasma corticoids, the present study compares the antidepressant effects of sertraline (10 mg/kg, i.p.) on behavioral changes elicited by (i) restraint stress (2.5. h/day for 13. days) and (ii) corticosterone injections (30. mg/kg, s.c., for 13. days). Stressed animals, but not corticosterone-treated animals displayed anxiety behavior and a reduction in the acquisition of a conditioned avoidance response to 25% of control levels (8.0 ± 2.2 vs. 31.7 ± 3.2), being this effect partly sensitive to sertraline. Stressed, but not corticosterone-treated, animals displayed an increased escape failure compared with the control group (24.6% ± 3.5 vs. 1.6 ± 0.7), an effect partly prevented by sertraline treatment (7.3% ± 2