Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
| Author | dc.contributor.author | Elia, Evelin M. | |
| Author | dc.contributor.author | Pustovrh, Carolina | |
| Author | dc.contributor.author | Amalfi, Sabrina | |
| Author | dc.contributor.author | Devoto, Luigi | |
| Author | dc.contributor.author | Motta, Alicia Beatriz | |
| Admission date | dc.date.accessioned | 2019-03-11T13:01:47Z | |
| Available date | dc.date.available | 2019-03-11T13:01:47Z | |
| Publication date | dc.date.issued | 2011 | |
| Cita de ítem | dc.identifier.citation | Fertility and Sterility, Volumen 95, Issue 8, 2018, | |
| Identifier | dc.identifier.issn | 00150282 | |
| Identifier | dc.identifier.issn | 15565653 | |
| Identifier | dc.identifier.other | 10.1016/j.fertnstert.2011.02.004 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/165270 | |
| Abstract | dc.description.abstract | Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect. © 2011 by American Society for Reproductive Medicine. | |
| Lenguage | dc.language.iso | en | |
| Publisher | dc.publisher | Elsevier Inc. | |
| Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| Source | dc.source | Fertility and Sterility | |
| Keywords | dc.subject | Lipoxygenases | |
| Keywords | dc.subject | metformin | |
| Keywords | dc.subject | peroxisome proliferator activated receptor gamma | |
| Keywords | dc.subject | polycystic ovary syndrome | |
| Keywords | dc.subject | uterus | |
| Título | dc.title | Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice | |
| Document type | dc.type | Artículo de revista | |
| dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
| Cataloguer | uchile.catalogador | SCOPUS | |
| Indexation | uchile.index | Artículo de publicación SCOPUS | |
| uchile.cosecha | uchile.cosecha | SI |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile