Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
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Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
Abstract
Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect. © 2011 by American Society for Reproductive Medicine.
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URI: https://repositorio.uchile.cl/handle/2250/165270
DOI: 10.1016/j.fertnstert.2011.02.004
ISSN: 00150282
15565653
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Fertility and Sterility, Volumen 95, Issue 8, 2018,
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