Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage
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2013Metadata
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Rodrigo Salinas, Ramón
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Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage
Abstract
Cardiovascular diseases are a leading cause of mortality and morbidity worldwide, with hypertension being a major risk factor. Numerous studies support the contribution of reactive oxygen and nitrogen species in the pathogenesis of hypertension, as well as other pathologies associated with ischemia/ reperfusion. However, the validation of oxidative stress-related biomarkers in these settings is still lacking and novel association of these biomarkers and other biomarkers such as endothelial progenitor cells, endothelial microparticles, and ischemia modified albumin, is just emerging. Oxidative stress has been suggested as a pathogenic factor and therapeutic target in early stages of essential hypertension. Systolic and diastolic blood pressure correlated positively with plasma F2-isoprostane levels and negatively with total antioxidant capacity of plasma in hypertensive and normotensive patients. Cardiac surgery with extracorporeal circulation causes an ischemia/reperfusion event associ
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URI: https://repositorio.uchile.cl/handle/2250/166125
DOI: 10.1155/2013/974358
ISSN: 18758630
02780240
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Disease Markers, Volumen 35, Issue 6, 2018, Pages 773-790
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