Glucose and Gluconate Metabolism in "Drinker" and "Nondrinker" Rats

Abstract

The rate of combustion of glucose-1-C<sup>14</sup>, 6-C<sup>14</sup> or U-C<sup>14</sup> (10 mmole/kg) and of gluconate-1-C<sup>14</sup> (1 mumole/kg) to expired CO<inf>2</inf> in intact rats of both sexes belonging to Ute "drinker" and "nondrinker" strains, was studied. Females of bolh s tra ins combusted glucose at a significantly higher rate than Ule respective males. The males of the "drinker" strain combusted carbon 1 of glucose at a significantly higher rate than U1e males of the "nondrinker" one. Rats of both sexes belonging to the "drinker" strain combusted carbon I of gluconate at significantly higher rates than those of lhe "nondrinker" one. In each strain, females exhibited a significanlly higher combustion rate of this carbon than the males. © 1964 S. Karger AG, Basel.