Downsizing class II lasso peptides: genome mining-guided isolation of huascopeptin containing the first Gly1-Asp7 macrocycle
Artículo

Open/ Download
Access note
Acceso Abierto
Publication date
2020Metadata
Show full item record
Cómo citar
Cortés Albayay, Carlos
Cómo citar
Downsizing class II lasso peptides: genome mining-guided isolation of huascopeptin containing the first Gly1-Asp7 macrocycle
Author
Abstract
A new lasso peptide, huascopeptin, was isolated following genome-mined discovery of a new biosynthetic gene cluster in extremotolerant Streptomyces huasconensis HST28(T) from Salar de Huasco, Atacama Desert, Chile. Compound 1 is a 13-residue class II lasso peptide containing a novel Gly1-Asp7 macrolactam ring, a three-residue loop, and a three-residue tail, making it the smallest lasso peptide isolated to date. The lasso structure was confirmed using NOE restraint-based molecular dynamics simulations.
Patrocinador
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT): PFCHA/DOCTORADO BECAS CHILE/2016-21160585
CONICYT Basal Centre Grant for the Centre for Biotechnology and Bioengineering, CeBiB: FB0001
University of Aberdeen
Indexation
Artículo de publicación ISI Artículo de publicación SCOPUS
Quote Item
J. Org. Chem. 2020, 85, 1661−1667
Collections
The following license files are associated with this item: