Isolation, gastroprotective effects and untargeted metabolomics analysis of lycium minutifolium J. Remy (Solanaceae)
Author
dc.contributor.author
Rodríguez, Stephanie
Author
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Walter Pertino, Mariano
Author
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Arcos, Chantal
Author
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Reichert, Luana
Author
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Echeverría, Javier
Author
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Simirgiotis, Mario
Author
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Bórquez, Jorge
Author
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Cornejo, Alberto
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Areche Medina, Carlos
Author
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Sepúlveda, Beatriz
Admission date
dc.date.accessioned
2020-08-13T23:26:07Z
Available date
dc.date.available
2020-08-13T23:26:07Z
Publication date
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2020
Cita de ítem
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Foods 2020, 9, 565
es_ES
Identifier
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10.3390/foods9050565
Identifier
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https://repositorio.uchile.cl/handle/2250/176421
Abstract
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Lycium minutifoliumJ. Remy (Solanaceae) is commonly used as an infusion in traditional medicine to treat stomach pain, meteorism, intestinal disorders, stomach ailments, and other severe problems including prostate cancer and stomach cancer. From the EtOAc extract ofL. minutifoliumbark five known metabolites were isolated using chromatographic techniques. The gastroprotective effects of the EtOAc fraction and edible infusion extract of the bark were assayed on the hydrochloric acid (HCl)/EtOH induced gastric ulcer model in mice to support the traditional use of the plant. The EtOAc extract and the edible infusion showed gastroprotective effect at dose of 100 mg/kg reducing lesions by 31% and 64%, respectively. The gastroprotective action mechanisms of the edible infusion at a single oral dose of 100 mg/kg were evaluated suggesting that prostaglandins, sulfhydryl groups, and nitric oxide are involved in the mode of gastroprotective action. The UHPLC analysis coupled to high-resolution mass spectrometry of the edible infusion showed the presence of twenty-three compounds. Our results can support the gastroprotective properties of the edible infusion extract, and at least can validate in part, the ethnopharmacological uses of the plant.
es_ES
Patrocinador
dc.description.sponsorship
Comisión Nacional de Investigación Científica y Tecnológica (CONICYT)
CONICYT FONDECYT
1180059
1170871
PAI/ACADEMIA
79160109