Plasma Tau Variants Detected by a Novel Anti-Tau Monoclonal Antibody: A Potential Biomarker for Alzheimer’s Disease
| Author | dc.contributor.author | González, Andrea | |
| Author | dc.contributor.author | Guzmán Martínez, Leonardo | |
| Author | dc.contributor.author | Maccioni Baraona, Ricardo | |
| Admission date | dc.date.accessioned | 2021-03-25T15:47:39Z | |
| Available date | dc.date.available | 2021-03-25T15:47:39Z | |
| Publication date | dc.date.issued | 2020 | |
| Cita de ítem | dc.identifier.citation | J Alzheimers Dis . 2020;77(2):877-883 | es_ES |
| Identifier | dc.identifier.other | 10.3233/JAD-200386 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/178796 | |
| Abstract | dc.description.abstract | Background: A major drawback in Alzheimer's disease (AD) is the lack of validated biomarkers for routine clinical diagnostic. We have reported earlier a novel blood biomarker, named Alz-tau (R), based on variants of platelet tau. This marker evaluates the ratio of high molecular weight tau (HMWtau) and the low molecular weight (LMWtau) tau. Objective: To analyze a potential novel source of antigen for Alz-tau (R), plasma tau, detected by immunoreactivity with the novel monoclonal antibody, tau51. Methods: We evaluated tau variants in plasma precipitated with ammonium sulfate from 36 AD patients and 15 control subjects by western blot with this novel monoclonal antibody. Results: The HMW/LMWtau ratio was statistically different between AD patients and controls. Conclusions: Plasma tau variants are suitable to be considered as a novel antigen source for the Alz-tau (R) biomarker for AD. | es_ES |
| Patrocinador | dc.description.sponsorship | Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) CONICYT FONDEF Corfo-Innova grant 12IDL2-18218 Ricardo Benjamin Maccioni Foundation | es_ES |
| Lenguage | dc.language.iso | en | es_ES |
| Publisher | dc.publisher | IOP Publishing | es_ES |
| Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | * |
| Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| Source | dc.source | Journal of Alzheimer's Disease | es_ES |
| Keywords | dc.subject | Alz-tau® | es_ES |
| Keywords | dc.subject | Alzheimer’s disease | es_ES |
| Keywords | dc.subject | HMW/LMWtau ratio | es_ES |
| Keywords | dc.subject | Monoclonal antibodies | es_ES |
| Keywords | dc.subject | Peripheral biomarkers | es_ES |
| Keywords | dc.subject | Tau protein in the human plasma | es_ES |
| Título | dc.title | Plasma Tau Variants Detected by a Novel Anti-Tau Monoclonal Antibody: A Potential Biomarker for Alzheimer’s Disease | es_ES |
| Document type | dc.type | Artículo de revista | es_ES |
| dcterms.accessRights | dcterms.accessRights | Acceso Abierto | |
| Cataloguer | uchile.catalogador | ctc | es_ES |
| Indexation | uchile.index | Artículo de publicación ISI | |
| Indexation | uchile.index | Artículo de publicación SCOPUS |
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile