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Longitudinal exposure to pyrethroids (3-PBA and trans- DCCA) and 2,4-D herbicide in rural schoolchildren of Maule region, Chile

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2020
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Muñoz Quezada, María Teresa
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Longitudinal exposure to pyrethroids (3-PBA and trans- DCCA) and 2,4-D herbicide in rural schoolchildren of Maule region, Chile
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Autor
  • Muñoz Quezada, María Teresa;
  • Lucero, Boris A.;
  • Gutiérrez Jara, Juan Pablo;
  • Buralli, Rafael J.;
  • Zúñiga Venegas, Liliana;
  • Muñoz, María Pía;
  • Vilches Ponce, Karina;
  • Iglesias, Verónica;
Resumen/Reseña
Background: Several studies showed that early exposure to pesticides affects the development and health of children. In Maule, there is previous evidence of the high exposure to organophosphate pesticides (OP) of schoolchildren. However, to date, there are no studies assessing exposure to pyrethroids and the herbicide 2,4-D. Objetive. To evaluate children's exposure to pyrethroids insecticides 3-phenoxybenzoic acid (3-PBA), trans 342,2dichloroviny1)-2,2-dimethylcyclopropane carboxylic acid (trans-DCCA) and 2,4 dichlorophenoxyacetic acid (24-D) herbicides. Method: Longitudinal study with 48 schoolchildren from two rural schools in the Maule region, Chile. Urinary metabolites of pyrethroids 3-PBA, Trans-DCCA and 24-D herbicides were evaluated in 2016 and 2017. Mann Whitney U for repeated measurements and Spearman's rho correlation tests were used for data analysis. Also, we used a system of impulsive differential equations for mathematical modeling. Results: All the schoolchildren assessed had more than two pesticide urinary metabolites in both years, with the 3-PBA metabolite being the most frequent. There was an increase in concentrations of urinary 3-PBA in November 2017, compared to 2016 (from 0.69 itgIL to 1.90 mu g(-1)). In 2016, the specific metabolites of 3-PBA were correlated with Trans-DCCA, 2,4-D, chlorpyrifos, diazinon, and para-nitrophenol. In 2017, 3-PBA was correlated with 2,4-D, and Trans-DCCA. The concentrations of 3-PBA of Chilean children were higher than studies conducted in the USA that found an association of prenatal exposure to these metabolites with cognitive difficulties. Conclusions: We found high concentrations of pyrethroid metabolites among all the schoolchildren assessed, which may impact on their health and development. These insecticides had received no attention from the sdentific community in Chile, and neither from the government agencies, despite the increased use of these chemicals in recent years. This is the first study in South America that confirms the exposure to pyrethroffis and herbicides through biomarkers in human population living near farm fields.
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Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 11150784 11190562 Agencia Nacional de Investigacion y Desarrollo (ANID) of the Chilean Government REDES 180078 PIA SOC180040
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URI: https://repositorio.uchile.cl/handle/2250/179357
DOI: 10.1016/j.scitotenv.2020.141512
Cita del ítem
Science of the Total Environment Volumen: 749 Número de artículo: 141512 Dec 2020
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