Docosahexaenoic and arachidonic acids as neuroprotective nutrients throughout the life cycle
Author
dc.contributor.author
Sambra Vásquez, Verónica Marcela
Author
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Echeverría González, Francisca Cecilia
Author
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Valenzuela, Alfonso
Author
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Chouinard Watkins, Raphaël
Author
dc.contributor.author
Valenzuela Báez, Rodrigo Wladimir
Admission date
dc.date.accessioned
2021-11-03T22:16:41Z
Available date
dc.date.available
2021-11-03T22:16:41Z
Publication date
dc.date.issued
2021
Cita de ítem
dc.identifier.citation
Nutrients 2021, 13, 986
es_ES
Identifier
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10.3390/nu13030986
Identifier
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https://repositorio.uchile.cl/handle/2250/182567
Abstract
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The role of docosahexaenoic acid (DHA) and arachidonic acid (AA) in neurogenesis and brain
development throughout the life cycle is fundamental. DHA and AA are long-chain polyunsaturated
fatty acids (LCPUFA) vital for many human physiological processes, such as signaling pathways, gene
expression, structure and function of membranes, among others. DHA and AA are deposited into the
lipids of cell membranes that form the gray matter representing approximately 25% of the total content
of brain fatty acids. Both fatty acids have effects on neuronal growth and differentiation through the
modulation of the physical properties of neuronal membranes, signal transduction associated with
G proteins, and gene expression. DHA and AA have a relevant role in neuroprotection against neurodegenerative
pathologies such as Alzheimer’s disease and Parkinson’s disease, which are associated
with characteristic pathological expressions as mitochondrial dysfunction, neuroinflammation, and
oxidative stress. The present review analyzes the neuroprotective role of DHA and AA in the extreme
stages of life, emphasizing the importance of these LCPUFA during the first year of life and in the
developing/prevention of neurodegenerative diseases associated with aging.
es_ES
Patrocinador
dc.description.sponsorship
Fondo Nacional de Desarrollo Cientifico y Tecnologico (National Fund for Scientific and Technological Research)
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT
University of Chile
University of Toronto
es_ES
Lenguage
dc.language.iso
en
es_ES
Publisher
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MDPI
es_ES
Type of license
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Attribution-NonCommercial-NoDerivs 3.0 United States