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Authordc.contributor.authorRosemblatt Bono, Mariana Violeta
Authordc.contributor.authorParra Tello, Brian Josué
Authordc.contributor.authorBriceño Catalán, Pedro Felipe
Authordc.contributor.authorRivas Yáñez, Elizabeth Camila
Authordc.contributor.authorTucer, Suat
Authordc.contributor.authorSaavedra Almarza, Juan Pablo
Authordc.contributor.authorHormann Cornejo, Pilar Leonor
Authordc.contributor.authorMartínez, Brandon A.
Authordc.contributor.authorLladser, Álvaro
Authordc.contributor.authorRosemblatt Silber, Mario César
Authordc.contributor.authorCekic, Caglar
Authordc.contributor.authorBono Merino, María Rosa
Authordc.contributor.authorSauma Mahaluf, Daniela Macarena
Cita de ítemdc.identifier.citationFrontiers in Cell and Developmental Biology April 2021 Volume 9 Article 647058es_ES
Abstractdc.description.abstractEcto-5 '-nucleotidase (CD73) is an enzyme present on the surface of tumor cells whose primary described function is the production of extracellular adenosine. Due to the immunosuppressive properties of adenosine, CD73 is being investigated as a target for new antitumor therapies. We and others have described that CD73 is present at the surface of different CD8+ T cell subsets. Nonetheless, there is limited information as to whether CD73 affects CD8+ T cell proliferation and survival. In this study, we assessed the impact of CD73 deficiency on CD8+ T cells by analyzing their proliferation and survival in antigenic and homeostatic conditions. Results obtained from adoptive transfer experiments demonstrate a paradoxical role of CD73. On one side, it favors the expression of interleukin-7 receptor alpha chain on CD8+ T cells and their homeostatic survival; on the other side, it reduces the survival of activated CD8+ T cells under antigenic stimulation. Also, upon in vitro antigenic stimulation, CD73 decreases the expression of interleukin-2 receptor alpha chain and the anti-apoptotic molecule Bcl-2, findings that may explain the reduced CD8+ T cell survival observed in this condition. These results indicate that CD73 has a dual effect on CD8+ T cells depending on whether they are subject to an antigenic or homeostatic stimulus, and thus, special attention should be given to these aspects when considering CD73 blockade in the design of novel antitumor therapies.es_ES
Patrocinadordc.description.sponsorshipComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1180385 1191438 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) AFB 170004 21151511 European Molecular Biology Organization (EMBO) IG3297 ANID 22190463 21201553 FONDEQUIP/EQM140016es_ES
Publisherdc.publisherFrontiers Mediaes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.uri*
Sourcedc.sourceFrontiers in Cell and Developmental Biologyes_ES
Keywordsdc.subjectCD8+T celles_ES
Keywordsdc.subjectAntigenic activationes_ES
Keywordsdc.subjectCD127 (IL7 receptor)es_ES
Títulodc.titleEcto-5′-nucleotidase (CD73) regulates the survival of CD8+ T cellses_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Indexationuchile.indexArtículo de publícación WoSes_ES

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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States