Altered gut microbiota in a fragile x syndrome mouse model
Author
dc.contributor.author
Altimiras, Francisco
Author
dc.contributor.author
García, José Antonio
Author
dc.contributor.author
Palacios García, Ismael José
Author
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Hurley, Michael J.
Author
dc.contributor.author
Deacon, Robert
Author
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González, Bernardo
Author
dc.contributor.author
Cogram, Patricia
Admission date
dc.date.accessioned
2021-12-22T12:31:02Z
Available date
dc.date.available
2021-12-22T12:31:02Z
Publication date
dc.date.issued
2021
Cita de ítem
dc.identifier.citation
Frontiers in Neuroscience May 2021 Volume 15 Article 653120
es_ES
Identifier
dc.identifier.other
10.3389/fnins.2021.653120
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/183354
Abstract
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The human gut microbiome is the ecosystem of microorganisms that live in the
human digestive system. Several studies have related gut microbiome variants to
metabolic, immune and nervous system disorders. Fragile X syndrome (FXS) is
a neurodevelopmental disorder considered the most common cause of inherited
intellectual disability and the leading monogenetic cause of autism. The role of the
gut microbiome in FXS remains largely unexplored. Here, we report the results of a
gut microbiome analysis using a FXS mouse model and 16S ribosomal RNA gene
sequencing. We identified alterations in the fmr1 KO2 gut microbiome associated
with different bacterial species, including those in the genera Akkermansia, Sutterella,
Allobaculum, Bifidobacterium, Odoribacter, Turicibacter, Flexispira, Bacteroides, and
Oscillospira. Several gut bacterial metabolic pathways were significantly altered in
fmr1 KO2 mice, including menaquinone degradation, catechol degradation, vitamin
B6 biosynthesis, fatty acid biosynthesis, and nucleotide metabolism. Several of these
metabolic pathways, including catechol degradation, nucleotide metabolism and fatty
acid biosynthesis, were previously reported to be altered in children and adults with
autism. The present study reports a potential association of the gut microbiome
with FXS, thereby opening new possibilities for exploring reliable treatments and
non-invasive biomarkers.
es_ES
Patrocinador
dc.description.sponsorship
Fragile X Research Foundation, United States
INF-PUCV Scholarship
grant CONICYT/FONDECYT/INICIACION 11180056
grant FONDECYT/POSTDOCTORAL 3190491
grant ANID PIA/BASAL FB0002
grant ANID/FONDECYT/REGULAR 1200928
es_ES
Lenguage
dc.language.iso
en
es_ES
Publisher
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Frontiers Media
es_ES
Type of license
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 United States