Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease
Author
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Chamorro, Nayaret
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Montero, David A.
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Gallardo Schall, Pablo Alfredo
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Farfán Urzúa, Mauricio
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Contreras, Mauricio
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Fuente, Marjorie, de la
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Dubois Camacho, Karen
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Hermoso, Marcela Alejandra
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Quera, Rodrigo
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Pizarro Guajardo, Marjorie
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Paredes Sabja, Daniel
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Ginard, Daniel
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Rossello Mora, Ramón
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Vidal Álvarez, Roberto
Admission date
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2022-05-16T17:39:02Z
Available date
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2022-05-16T17:39:02Z
Publication date
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2021
Cita de ítem
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Microbial Cell September 2021 | Vol. 8 No. 9
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Identifier
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10.15698/mic2021.09.760
Identifier
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https://repositorio.uchile.cl/handle/2250/185542
Abstract
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Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn's disease (CD), cause chronic inflammation of the gut, affecting millions of people worldwide. IBDs have been frequently associated with an alteration of the gut microbiota, termed dysbiosis, which is generally characterized by an increase in abundance of Proteobacteria such as Escherichia coli, and a decrease in abundance of Firmicutes such as Faecalibacterium prausnitzii (an indicator of a healthy colonic microbiota). The mechanisms behind the development of IBDs and dysbiosis are incompletely understood. Using samples from colonic biopsies, we studied the mucosa-associated intestinal microbiota in Chilean and Spanish patients with IBD. In agreement with previous studies, microbiome comparison between IBD patients and non-IBD controls indicated that dysbiosis in these patients is characterized by an increase of pro-inflammatory bacteria (mostly Proteobacteria) and a decrease of commensal beneficial bacteria (mostly Firmicutes). Notably, bacteria typically residing on the mucosa of healthy individuals were mostly obligate anaerobes, whereas in the inflamed mucosa an increase of facultative anaerobe and aerobic bacteria was observed. We also identify potential co-occurring and mutually exclusive interactions between bacteria associated with the healthy and inflamed mucosa, which appear to be determined by the oxygen availability and the type of respiration. Finally, we identified a panel of bacterial biomarkers that allow the discrimination between eubiosis from dysbiosis with a high diagnostic performance (96% accurately), which could be used for the development of non-invasive diagnostic methods. Thus, this study is a step forward towards understanding the landscapes and alterations of mucosaassociated intestinal microbiota in patients with IBDs.
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Patrocinador
dc.description.sponsorship
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT 1161161
Spanish Government CLG2015 66686-C3-1-P
European Commission
National Science Foundation (NSF) OCE-1342694
Millennium Science Initiative from the Ministry of Economy, Development and Tourism
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT 1120577
1170648
CONICYT-PCHA/2014-21140975
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Lenguage
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en
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Publisher
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Shared Science
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Type of license
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Attribution-NonCommercial-NoDerivs 3.0 United States